1/22/2023 0 Comments Ck2 after the end![]() ![]() Results: Using these methods, we showed that CK2.3 stimulation activated OSX, ALP, and OCN. We then confirmed the results in primary BMSCs. Methods: Using a newly developed fluorescent CK2.3 analog, specific inhibitors for the BMP signaling pathways, Western blot, and RT-qPCR, we determined the mechanism of CK2.3 in C2C12 cells. However, the detailed signaling pathways, the time frame of signaling, and genes activated remain largely unknown. ![]() It induces osteogenesis and bone formation in vitro and in vivo by acting downstream of BMPRIA through releasing CK2 from the receptor. CK2.3, a novel peptide, may be a potential therapeutic. Background: Osteoporosis is a degenerative skeletal disease with a limited number of treatment options.
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